Adaptive Platform Trials Scientific Meeting

October 3, 2024
Chestnut Conference Centre, Toronto, ON, Canada



Understand the key elements of designing and implementing adaptive platform trials.


Gain insights into the operational aspects of adaptive platform trials, such as protocol development, CRF design, data management, and the role of standardization and operational documents.


Understand the importance of pre-trial model-based simulations and interim statistical analyses for adaptive platform trials.

Ethics Approval

Learn about the ethical considerations, best practices, and the role of Research Ethics Boards in operationalizing ethical guidelines throughout adaptive platform trials.


Explore strategies for effective engagement and involvement of participants, including patients and other stakeholders, in the adaptive platform trial process.


Connect and learn with experts, researchers, professionals, and trainees working on adaptive platform trials.


APT Design

Overview of the basics of adaptive platform trials (APTs) and suitable questions for an APT

Dr. John Marshall

How to design an adaptive platform trial

Platform structure (includes defining treatment arms, assessing patient eligibility status, and identifying patient characteristics or biomarkers that form the basis for stratification into subgroups)

The role of simulation in planning (how simulations are used to predict trial outcomes, optimize design parameters, and prepare for adaptive decision-making processes within the trial)

Dr. Ben Saville

Algorithms and methodologies for the analysis of data generated by adaptive trials

Dr. Lorenzo Trippa

Panel discussion: Lessons from previous APTs

Chair/Moderator: Dr. John Marshall
Panelists: Dr. Andrew Pinto, Dr. Niall Ferguson, Dr. Lorenzo Trippa, and Dr. Ben Saville

APT Operations

Operational aspects of adaptive platform trials

  • Registering your trial
  • Modular approach to protocol (master protocol & sub-protocols)
  • Research coordinator perspective – challenges and solutions – Importance of standardization, role of operational documents and SOPs
  • Data management, especially dynamic aspects
  • Management, governance, site contracts

Dr. Francesca Schiavone

Panel discussion: Reflect on real-world challenges in the operational aspects of APTs and discuss strategies to address them)

Chair/Moderator: Dr. Andrew Pinto

Panelists: Dr. John Marshall, Dr. Benita Hosseini, Dr. Niall Ferguson, Dr. Lorenzo Trippa, and Dr. Ben Saville

APT Implementation

Interactive mock REB meeting

Participants will review a short proposal idea for an adaptive platform trial, discuss it in the context of research ethics, and provide feedback

Dr. Ross Upshur

Transparent consent in APTs

Explaining APTs to patients and truly informed consent

Dr. Jarome Singh

Participant engagement and implementing Good Participatory Practices in APTs

Dr. Lisa Schwartz

Funding strategies and models to support the sustainability of APTs

Dr. Andrew Pinto

Meet the speakers

Dr. Andrew Pinto

Upstream Lab

Dr. Ben Saville

Adaptix Trials, LLC

Dr. Benita Hosseini

Upstream Lab

Dr. Francesca Schiavone

University College London

Dr. Jerome Singh

University of KwaZulu-Natal

Dr. John Marshall

St. Michael’s Hospital

Dr. Lisa Schwartz

McMaster University

Dr. Lorenzo Trippa

Harvard University

Dr. Niall Ferguson

University of Toronto

Dr. Ross Upshur

University of Toronto

Share your research

Call for abstracts

Submit original research or applications related to adaptive platform trials (APTs). Topics include trial design, implementation challenges, statistical methodologies, and findings of APTs.

Scientific Committee

Benita Hosseini


Andrew Pinto


Robert Fowler


Shirin Golchi


Learn. Connect. Transform.

The APT Scientific Meeting is for clinical trialists, clinical investigators, statisticians, trial methodologists, health economists, policymakers, patient advocates, and trainees interested in the use, design and implementation of platform trials.

Sponsors and Supporters

The Upstream Lab is organizing the 2024 Adaptive Platform Trials Scientific Meeting. This non-profit research group, based at the MAP Centre for Urban Health Solutions, St. Michael’s Hospital, is dedicated to improving the health and well-being of the population by addressing social determinants of health, using artificial intelligence, and conducting trials.

Get in touch

Questions? Contact

Date: October 3, 2024
Time: 9:00 am to 5:00 pm


University Room – 3rd Floor
Chestnut Conference Centre
89 Chestnut St
Toronto, ON M5G 1R1

We acknowledge that this event is happening on the traditional territory of many nations including the Mississaugas of the Credit, the Anishnabeg, the Chippewa, the Haudenosaunee, and the Huron-Wendat peoples and is now home to many diverse First Nations, Inuit, and Métis. We also acknowledge that Toronto is covered by Treaty 13 with the Mississaugas of the Credit.

The APT Scientific Meeting is for clinical trialists, clinical investigators, statisticians, trial methodologists, health economists, trainees, policymakers, patient advocates, and anyone interested in the use, design and implementation of platform trials.

Click here to register.

Registration fees:

  • $30 CAD for trainees and students
  • $60 for professionals

Yes, abstract submissions are welcome. Please refer to the abstract submission guidelines for specific format, deadlines, and submission process instructions.

We appreciate your interest in contributing to the conference. Please contact our organizing committee at to inquire about speaking at the APT Scientific Meeting. We welcome diverse perspectives and expertise.

Yes, the APT Scientific Meeting will be available online for virtual attendance. Virtual attendees will have access to live and recorded sessions and the ability to participate in Q&A sessions.