Master Protocol

Appendix 4.3 – Recruitment Poster – February 14 2023 – Clean

Appendix 4.3a – Social Media Posts and Accounts – January 13 2023 Clean

Appendix 4.3b – Recruitment Poster 2 – February 9 2023

Appendix 4.3g – Email to companies – January 13 2023 (see note below about email of support from the institution)

Appendix 4.3h – Recruitment email – January 13 2023

Appendix 4.3i – Outreach from Workplace Health COVID-19 Team – January 13 2023

Appendix 4.3j – Recruitment video script – January 13 2023

Appendix 4.3k – Recruitment Poster 3 – February 14 2023

Appendix 4.4 – Letter to PBRN associated providers – Nov 3 2022 Clean

Appendix 4.5 – Letter to PBRN associated patients from providers – Nov 3 2022 Clean

Appendix 4.6 – Letter to providers after patient enrollment – Nov 3 2022 Clean

Appendix 4.7 – Online self-screening form – EN and FR – Jan 5 2023

Appendix 5 – DSMC charter – July 27 2022

Appendix 6.1 – ISA usual care – Aug 1 2022

Appendix 7.1 – Study co-investigators – Oct 13 2022 Clean

Appendix 7.2 – Committee members – Sept 9 2022

Appendix 8 – Adverse Event Log – Sept 9 2022

Appendix 9 – Medication Log – Sept 9 2022

Appendix 10 – Amendment tracker – Oct 28 2022 Clean

Appendix 10 – Amendment tracker – Oct 28 2022 Tracked Changes

Appendix 11 – Protocol Deviation Log – Sept 29 2022

Appendix 12 – Toll-free phone line contacts – Sep 29 2022

Provincial Amendment 2 Request Letter – Nov 15 2022

Provincial Amendment 3 Request Letter – Jan 11 2023

Provincial Amendment 4 Request Letter – February 14 2023

Note: Appendix 4.3j – Recruitment video script – January 13 2023 requires a letter of support from that institution before distribution. This can be provided in emails of support that can be submitted to this REB as they are enlisted. Furthermore, some of these institutions may need to confirm internally if REB approval is required to recruit at those sites and if applicable can be obtained separately or as a centre within CTO via CIA – it is the responsibility of these institutions to verify this.

Please email Celine at celine.jeanxavier@utoronto.ca to let her know that you have read and understood those requirements and that you will follow them.

Recruitment Materials

The recruitment posters and social media graphics were created on Canva, an online design website.

To access the editable versions of the materials:

  1. Create a free account on Canva
  2. Click the design links below
  3. Create a copy of the design for your hub before editing. Do not edit the original files. To duplicate the designs,
    • Open the design you want to duplicate.
    • Click File from the status bar above the editor.
    • Click Make a copy. The duplicated design will open in a new tab.

Links to designs

Training Materials

Site Initiation Visit – Ontario

Protocol Training Video

Study Conduct and Database Training

Database Demonstration

Key Messages

We have developed these key messages for all investigators, staff and trainees involved in CanTreatCOVID. Please use this to support awareness of the study and our findings.

  1. We are evaluating the effectiveness of existing and emerging treatments for acute COVID-19 in primary care and community settings. Importantly, our study will go beyond nirmatrelvir/ritonavir (Paxlovid).
  2. We are also studying whether any acute treatment can prevent long COVID.
  3. We are building our adaptive platform trial to be useful for other respiratory infections and help with future pandemics.