SAVE THE DATE
Adaptive Platform Trials Scientific Meeting 2024

OCTOBER 3

Thank you!

Thank you for attending the APT Scientific Meeting from September 28 to 29, 2023. You can download the presentations and watch the session recordings below.

View more photos

Presentations

Day 1: September 28

Introduction to adaptive platform trials and their advantages over traditional randomized controlled trials

09:15-10:00

Understand the basics of adaptive platform trials and their advantages over traditional randomized controlled trials

Dr. Angela Cheung

Download the slides

Case studies of adaptive platform trials with complex designs such as trials with multiple arms or multiple stages in different disease areas.

10:00-12:00

Learn about complex adaptive platform trials and their designs:

1 simple and elegant APT study involving response-adaptive randomization: Dr. John Marshall (REMAP-Cap) Download the slides

1 simple and elegant study involving adaptive intervention arms: Dr. Jamie Forrest (TOGETHER) Download the slides

1 large study that adopted a traditional RCT design, but would have benefited from an adaptive platform trial design: Dr. Rubeshan Perumal
Contact Dr. Perumal for questions about his presentation: Rubeshan.Perumal@caprisa.org

Bayesian analysis in adaptive trials: sample size calculation, simulation, and sequential hypothesis testing

13:00-13:45

Learn practical techniques for conducting simulation studies for sample size estimation, and gain understanding of Bayesian methods and sequential hypothesis testing in the context of adaptive platform trials

Dr. Anna Heath

Download the slides

Hands-on practice session for statistical design of Bayesian adaptive trials

13:45-14:30

Learn about the statistical considerations in design of Bayesian adaptive trials and performing simulation studies required for the design. Attendees will have access to worked out examples presented using R.

Dr. Haolun Shi

Adaptive Trial Designs for Public and Global Health

14:30- 15:15

Learn about the Bayesian adaptive trial design through two case studies: 1) a multi-arm, multi-stage adaptive trial design with individually RCT; 2) an adaptive cluster RCT

Dr. Ofir Harari

Download the slides

P-value and Bayesian analysis in randomized-controlled trials in child health research published in 2007 and 2017: a methodological review

15:15- 16:00

To examine whether Bayesian methodology offers a more reliable alternative to traditional frequentist methods in conducting child health research trials, and to investigate if there’s a significant clustering around P-values in randomized controlled trials (RCTs) within this field, using data from two cohorts published in 2007 and 2017

Dr. Alex Aregbesola

Download the slides

Trainee Lightning Presentations

16:15-16:30
Evaluating Platform Designs for Clinical Trials in Patients with Mild Cognitive Impairment (Presenter: Qirui (Dylan) Hou; University of Toronto) Download the slides

16:30- 16:45
This is our chance to get results fast”: Moral experiences of clinician-investigators and staff involved in adaptive trials during the first wave of the COVID pandemic (Presenter: Rachel Yantzi, McMaster University) Download the slides

16:45- 17:00
Identifying Patient Subgroups with Treatment Effect Heterogeneity in Adaptive Platform Trials (Presenter: Xianglin Zhao; McGill University) Download the slides

17:00- 17:15
Enhancing the Efficiency of Adaptive Platform Trials Through the Exploration of Alternative Treatment Ranking Methods (Presenter: Abigail McGrory, University of Toronto) Download the slides