Adaptive Platform Trial Scientific Meeting

SEPTEMBER 28-29, 2023
CHESTNUT CONFERENCE CENTRE, TORONTO, ON

Thank you!

Thank you for attending the APT Scientific Meeting. You can download the presentations and watch the session recordings below.

Presentations

Day 1: September 28

09:15-10:00

Understand the basics of adaptive platform trials and their advantages over traditional randomized controlled trials

Dr. Angela Cheung

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10:00-12:00 

Learn about complex adaptive platform trials and their designs:  

1 simple and elegant APT study involving response-adaptive randomization: Dr. John Marshall (REMAP-Cap) Download the slides

1 simple and elegant study involving adaptive intervention arms: Dr. Jamie Forrest (TOGETHER) Download the slides

1 large study that adopted a traditional RCT design, but would have benefited from an adaptive platform trial design: Dr. Rubeshan Perumal
Contact Dr. Perumal for questions about his presentation: Rubeshan.Perumal@caprisa.org 

13:00-13:45

Learn practical techniques for conducting simulation studies for sample size estimation, and gain understanding of Bayesian methods and sequential hypothesis testing in the context of adaptive platform trials

Dr. Anna Heath

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13:45-14:30

Learn about the statistical considerations in design of Bayesian adaptive trials and performing simulation studies required for the design. Attendees will have access to worked out examples presented using R.

Dr. Haolun Shi

14:30- 15:15

Learn about the Bayesian adaptive trial design through two case studies: 1) a multi-arm, multi-stage adaptive trial design with individually RCT; 2) an adaptive cluster RCT

Dr. Ofir Harari

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15:15- 16:00

To examine whether Bayesian methodology offers a more reliable alternative to traditional frequentist methods in conducting child health research trials, and to investigate if there’s a significant clustering around P-values in randomized controlled trials (RCTs) within this field, using data from two cohorts published in 2007 and 2017

Dr. Alex Aregbesola

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16:15-16:30
Evaluating Platform Designs for Clinical Trials in Patients with Mild Cognitive Impairment (Presenter: Qirui (Dylan) Hou; University of Toronto) Download the slides

16:30- 16:45
This is our chance to get results fast”: Moral experiences of clinician-investigators and staff involved in adaptive trials during the first wave of the COVID pandemic (Presenter: Rachel Yantzi, McMaster University) Download the slides

16:45- 17:00
Identifying Patient Subgroups with Treatment Effect Heterogeneity in Adaptive Platform Trials (Presenter: Xianglin Zhao; McGill University) Download the slides

17:00- 17:15
Enhancing the Efficiency of Adaptive Platform Trials Through the Exploration of Alternative Treatment Ranking Methods (Presenter: Abigail McGrory, University of Toronto) Download the slides

Day 2: September 29

8:30-9:30

To discuss ethical challenges in adaptive platform trial design and analysis and explore solutions

Dr. Ross Upshur

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9:30-10:15

Discuss practical challenges in adaptive platform trials and how to overcome them

Dr. Ly-Mee Yu

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10:30-11:15

To present reflections on ethical and practical challenges of implementing GPP-EP for adaptive platform trials from experience during COVID-19

Dr. Lisa Schwartz

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11:15-12:00

Learn about grant writing and protocol development for adaptive platform trials

Dr. Andrew Pinto

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Scientific Committee

Andrew Pinto

MD CCFP FRCPC MSc

Benita Hosseini

PhD

Angela Cheung

PhD, MD, FRCPC

Alan Katz

CCFP, MBChB, MSc

Rubeshan Perumal

MPH, MMed, MPhil

Sponsors

Conference Objectives

Understand the concept and advantages of adaptive platform trials over traditional randomized controlled trials

Understand the statistical methods used in adaptive platform trials, including Bayesian methods and sequential hypothesis testing

Identify the practical challenges associated with adaptive platform trials and learn how to address them

Attendees

Scientists, Statisticians, Clinical Project Managers, Clinical Research Advisors, Clinical Trial Directors, Early Career Researchers and Trainees

Presenters

Experts from Canada, United Kingdom and South Africa shared their work at the APT Scientific Meeting

Abstracts

Trainees presented their research showing relevance to APTs or evaluating APT design, methods or approach in comparison to other studies